Blocking nitric oxide, a common brain gas, reverses autism-like traits in mice. Treating human nerve cells with nitric oxide blocker produced a similar result. In addition, samples from autistic children contained much lower levels of the TSC2 brake protein that blocks nitric oxide.

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While Stanton collected a promising cast for his film, the reviews out of its Sundance debut were bleak. And we can confirm, this movie is a mess. Imagine Black Mirror without nuance or Cloud Atlas without ambition, and you'll have some idea. The Neanderthal plot, which features no modern dialogue, is the most impactful thread. The rest is confounding and bland. — Kristy Puchko, Entertainment Editor

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Monday’s plunge adds to a steep slide in Asia’s markets since Trump’s Iran strikes. The KOSPI is down by over 16% since the Iran war began. Japan’s Nikkei 225 and Australia’s ASX 200 are down by around 10% and 6% respectively over the same period.

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