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Specialized σ factors interact with nuclease-dead, CRISPR–Cas12f proteins to form potent, RNA-guided gene activation systems that function independently of fixed promoter motifs.

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What is Connections?The NYT's latest daily word game has become a social media hit. The Times credits associate puzzle editor Wyna Liu with helping to create the new word game and bringing it to the publications' Games section. Connections can be played on both web browsers and mobile devices and require players to group four words that share something in common.

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